Potential benefits of one phytochemical, ellagic acid, include decreasing cancer risk and lowering cholesterol. The full text of this article hosted at is unavailable due to technical difficulties. Mar 04, 2014 searching for new anticancer agents from plant sources is a realistic and promising approach which may lead to the discovery of many novel anti cancer drugs3, 4. Recent in vitro and in vivo experiments have revealed that ea elicits anticarcinogenic effects by inhibiting tumor cell proliferation. Oct 02, 2019 ellagic acid is a naturally occurring polyphenolic constituent found in 46 different fruits and nuts such as grapes, pomegranate, red raspberry, strawberry, blueberry, and walnuts. The bottom line is that it is the ellagitannins that are present in various fruits not the ellagic acid. European medical studies also demonstrate that ellagic acid is known to lower the incidence of birth defects, promote wound healing, reduce heart disease, and may reduce or reverse chemically induced liver fibrosis. To determine whether dietary berries and ellagic acid prevent 17. This doesnt mean that you should run out and purchase ellagic acid supplements.
Effects on pglycoprotein efflux activity in 22rv1 cells of 0. Overview research in animal and laboratory models has found that ellagic acid inhibits the growth of tumors caused by certain carcinogens. Ea is a dimeric derivative of gallic acid, which may occur either as a free form or as a complex within ets in high quantity in a variety of berries e. Recent in vitro and in vivo experiments have revealed that ea elicits anticarcinogenic effects by inhibiting tumor. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption. Ellagic acid inhibits bladder cancer invasiveness and in vivo tumor growth. According to some sources, ellagic acid prevents the binding of carcinogens to dna and strengthens connective tissue, which may keep cancer cells from spreading. Cancer is a leading cause of death in developed and developing countries1, 2. Ellagic acid is a phenol found in red raspberries, arctic. Ellagic acid shows different antiproliferative effects between the. Results and discussion chromatograms for the test samples subjected to identification and quantification of ellagic acid are presented in figure 1. Ellagic acid is a naturally occurring compound called a tannin, found in red raspberries, strawberries, pomegranates, and walnuts. Food and drug administration as a fake cancer cure consumers should avoid.
The truth about ellagic acid and red raspberries baseline. Searching for new anticancer agents from plant sources is a realistic and promising approach which may lead to the discovery of many novel anti cancer drugs3, 4 ellagic acid ea is a naturally occurring phenolic constituent that is contained in ellagitannins in grapes, nuts, strawberries, black. Ellagic acid is an antioxidant and an antiproliferative compound present in fruits, nuts and vegetables. European medical studies also demonstrate that ellagic acid is known to lower the incidence of birth defects, promote wound healing, reduce heart disease, and may reduce or reverse chemically induced liver. Ellagic acid is a compound found in raspberries, strawberries, cranberries, walnuts, pecans, pomegranates, and other plant foods. Ellagic acid attenuates immunoglobulin emediated allergic. Lycopene a powerful antioxidant found in tomatoes and tomato products such as tomato sauce and watermelon, lycopene may reduce the risk of prostate cancer. The current study sought to determine the role and regulation of actn4 expression in human breast cancer metastasis and eabased. Expl ther ellagic acid seems to have some anti cancer properties. According to some sources,ellagic acid prevents the binding of carcinogens to dna and strengthens connective tissue, which may keep cancer cells from spreading. Fourth, ellagic acid helps prevent cancer, birth defects, etc. It was interesting to find the radioprotective effect of ea on nih3t3, which is a normal cell line.
Ellagic acid memorial sloan kettering cancer center. Ellagic acid has been marketed as a dietary supplement with a range of claimed benefits against cancer, heart disease, and other medical problems. A simple hplcuv method has been developed and validated for the quantification of ellagic acid ea in ethanol extracts of eugenia uniflora l. Previous studies have reported the antitumor properties of ea mainly using in vitro models. Ellagic acid dosedependently reduced histamine release and the expression and secretion of proin. Some articles in which ellagitannins are quantified refer to ellagic acid because quantitation of ellagitannins is done by breaking them down into ellagic acid subunits and quantifying the subunits. Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. Pdf there is currently a shifting focus towards finding natural compounds that may prevent or treat cancer, due to the problems that exist with. Again, to quote from the washington state red raspberry commission. The antioncogenic influence of ellagic acid on colon cancer. Ellagic acid cancer treatment homepage cancer tutor.
The aim of this study was to elucidate if resveratrol or ellagic acid, respectively, could improve the efficacy of cisplatin in ovarian cancer. Ellagic acid is a naturally occurring polyphenolic constituent found in 46 different fruits and nuts such as grapes, pomegranate, red raspberry, strawberry, blueberry, and walnuts. Pdf ellagic acid chemopreventive role in oral cancer. This is promising, at this time, there is a lot of ongoing research to find evidence from human clinical studies showing that ellagic acid in any form can prevent or treat cancer.
Several natural antioxidants, including ellagic acid ea, have been reported to have chemotherapeutic activity in vivo and in vitro settings. Extraction, stability, and quantitation of ellagic acid in. Punica granatum pomegranate and its constituent ellagic acid ea are recently more taken into accounts since their promising pharmacological effects. Ellagic acid enhances apoptotic sensitivity of breast cancer. In vitro studies on the mechanism of action of two compounds with antiplasmodial activity. Searching for new anticancer agents from plant sources is a realistic and promising approach which may lead to the discovery of many novel anticancer drugs3, 4 ellagic acid ea is a naturally occurring phenolic constituent that is contained in ellagitannins in grapes, nuts, strawberries, black. Ellagic acid is a potential chemopreventive agent against skin cancer. Ellagic acid is found in many foods that are part of a healthy diet, but there is no evidence to support its use for cancer treatment.
The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, and walnuts medicinally, ellagic acid is used to prevent cancer and treat viral and bacterial infections. Evidencebased complementary and alternative medicine hindawi. Ellagic acid ea and tannic acid ta are phenolic acids found in a wide variety of fruits and nuts such as raspberries, strawberries, pomegranate, walnuts, grapes, and blackcurrants. Ellagic acid is a plant chemical rumored to offer a number of powerful health benefits. Pdf ellagic acid chemoprotective role in oral cancer. Mar, 2019 effects on pglycoprotein efflux activity in 22rv1 cells of 0. Investigation of the effectiveness of ea in a leptinenriched model might have been given a little interest. Nov 28, 2018 ellagic acid caused breast cancer cells to selfdestruct and stopped them from spreading, in a separate study reported in the april 2015 issue of the international journal of oncology. Multiple effects of ellagic acid on human colorectal carcinoma cells. Ellagic acid inhibits bladder cancer invasiveness and in vivo.
In spite of evidences for anticancer activity in various cancer celllines, human cancer. The quantities of ellagic acid were based on peak areas, and expressed as mg100 g fw or mg100 g juice. Ellagic acid caused breast cancer cells to selfdestruct and stopped them from spreading, in a separate study reported in the april 2015 issue of the international journal of oncology. Ellagic acid, pomegranate and prostate cancer a mini. Food and drug administration as a fake cancer cure. Efficiently inhibits colon cancer cell growth through a mechanism involving wnt16. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. Research progress on the anticarcinogenic actions and mechanisms of ellagic acid. Pomegranate husk powder mesh size 5060, advait herbal extracts, tumkur, india was used in the extraction of ellagic acid based on a reported procedure by jingjing lu et al. The inhibitory effect of ellagic acid on cell growth of. However, not many papers dealing with the electrochemical properties and protolytic equilibria of ellagic acid have been published so far.
Colorectal cancer is crc the thirdmost common cancer worldwide and the second leading cause of death. Ceci c, tentori l, atzori mg, lacal pm, bonanno e, scimeca m. Ellagic acid ea is a polyphenolic compound from the family of ellagitannins ets, historically identified as the active compound responsible for the antioxidant properties of pomegranate punica granatum. Abstract ellagic acid is a biologically active polyphenol found in numerous fruits and vegetables. Furthermore, it is considered to be a cancer inhibitor which has the ability to cause apoptosis or normal cell death in cancer cells. In a website report outlines that ellagic acid may slow the development of some cancerous cells. Ionizing radiation works by inducing damage not only at the molecular, cellular, tissues and organ system but also at the whole body system either directly or indirectly.
The dietary anticancer agent ellagic acid is a potent inhibitor of dna topoisomerases in vitro. Radiosensitiser, cancer, radiation therapy, ellagic acid introduction cancer therapy still depends on ionizing radiation as one of its most effective tools. Ellagic acid enhances the activity of certain detoxification enzymes in the liver, speeding up the removal of dangerous substances from the body, while it also inhibits the cytochrome p450 liver enzymes and may. Ellagic acid induces hela cell apoptosis via regulating. The world health organization who classifies lung cancer into two subtypes. The benefits of ellagic acid healthy eating sf gate. Ellagic acid ea is a naturally occurring phenolic constituent that is contained in ellagitannins in grapes, nuts, strawberries, black currents, raspberries, green tea, pomegranates. Ellagic acid alkali metal salts, sodium salt or magnesium salt can be used as uv absorbents. Ellagic acid supplements red raspberry tablets and powder. The fact that the phosphatidylinositol 3 kinase pi3k signaling pathway is one of the most frequently deregulated signaling networks has triggered intensive efforts in the development of pi3k pathway inhibitors. Direct inhibition of actn4 by ellagic acid limits breast.
Ellagic acid is a powerful antioxidant, polyphenol found in red raspberries, arctic bramble, and cloudberries strawberries and walnuts. Pharmacologybased target identification has become a novel strategy leading to the discovery of novel pathological biomarkers. In a 2014 study, research suggests that ellagic acid slows the. In a published report states that ellagic acid may slow the growth of some cell abnormalities. Extraction of ellagic acid royal society of chemistry. Stop tumor growth and kill cancer cells naturally with. Accidental release measures contain spill and collect, as appropriate. Experimental evidence of the antitumor, antimetastatic and. How effective is ellagic acid in the 1990s the hollings cancer center at the medical university of south carolina in charleston, headed up by dr.
Research article ellagic acid inhibits migration and invasion. Next up on our list of foods rich in ellagic acid is the pomegranate. M and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and. However, the effect of hormonal therapy is temporary, and most tumors become androgen refractory, which obstacle in the treatment of metastatic prostate cancer. Pdf research progress on the anticarcinogenic actions and. Ellagic acid was reported to be a potent inhibitor of ck2 in virtual screening study 65. Recommended level for topical application for skin preparations, such as sunscreen, skin whitening, wound healing and antiinflammatory creams 0. Effects of black raspberries and their ellagic acid and. Ellagic acid inhibits bladder cancer invasiveness and in.
Ellagic acid ea, a dietary polyphenol compound, exhibits potent anticancer activities. You can comfortably view more of these informative videos at. This study describes the effect of the flavonoid ellagic acid ea on gammairradiated human breast cancer mcf7 cells in vitro when administered alone or in combination with radiation. Here in, we investigated the antitumor effect of ea in the presence of leptin to reflect on therapeutic use of ea in obesitylinked colon cancer. Phytochemicals chemicals found in plant foods might have health benefits that explain why fruits and vegetables are good for you, just like your mom said. Although the amounts of free ellagic acid in the pomegranate fruit are relatively low compared with fruits like cultivated strawberries or blackberries, this gorgeous red fruit has high levels of total ellagic acid thanks to the high amounts of ellagitannins it contains. Berries and ellagic acid prevent estrogeninduced mammary. In other lab studies, ellagic acid seems to reduce the effect of estrogen in promoting growth of breast cancer cells in tissue cultures. Lung cancer is the most commonly diagnosed tumour worldwide 11. The electrooxidation mechanism of ellagic acid was studied in methanol aqueous media 1. Ellagic acid 476664 2,3,7,8tetrahydroxychromeno5,4,3cdechromene5,10dione as a very potent ck2 inhibitor ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. Ovarian carcinoma es2 and pa1 cells were treated with ea 10 100.
M and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and their molecular mechanisms. Moreover, ellagic acid suppressed an increase in intracellular calcium ion concentration ca2 i in. In addition to its antioxidant benefits, ellagic acid has been researched for its ability to fight cancer and other diseases. Research progress on the anticarcinogenic actions and.
No data are available about ea influence on bladder cancer cell invasion of the extracellular matrix triggered by vascular. Ellagic acid at the three investigated doses induced g1 cell cycle arrest in hela cells, as evidenced by the significantly increased proportion of cells at the g1 phase 69. Folic acid folate has a preventive effect on colorectal cancer. Ellagic acid, a phenolic compound, exerts antiangiogenesis effects via vegfr2 signaling pathway in breast cancer. Ellagic acid ea is a polyphenolic compound that can be found as a naturally occurring hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts. It can act as an antioxidant, and has been found to cause apoptosis cell death in cancer cells in the lab. As a cellular resistance model, the epithelial ovarian cancer cell line a2780 and its cisplatinresistant subclone a2780cisr were used. Its been marketed as a cure for cancer, for example, and appears to have powerful antioxidant benefits. Daniel nixon, conducted a nineyear research study on the properties of ellagic acid, which included a double blind study involving 500 cervical cancer patients. Human research reveals that the body readily absorbs ellagic acid from red raspberries, leading to inhibition of. Ellagic acid ea is able to inhibit the growth of several cancer cells. Jul 26, 2016 ellagic acid ea has been proposed as a promising candidate for therapeutic use in colon cancer.
Introduction there is an inverse correlation between individuals who consume a diet rich in fruits and vegetables and their risk of developing cancer committee on diet, nutrition, and cancer, 1982. Evidencebased complementary and alternative medicine. Cytochrome p450 cyp activity and synthesis of both epoxyeicosatrienoic acids eets and 20hydroxy5,8,11,14eicosatetraenoic acid 20hete, together with vascular endothelial growth factor vegf and heme oxygenase system ho have. While this is encouraging, at the moment, there is no consistant reserach attainable from human scientific research proving that ellagic. D ellagic acid, a phenolic acid is found in berries raspberries, strawberries, pomegranate, grapes, and nuts acts as an antioxidant. In spite of evidences for anticancer activity in various cancer celllines, human cancer cells, the mechanistic role of ellagic acid is not. It has shown positive attributes in esophageal and colon cancer in animals studies and possibly prostate cancer. The ellagic acid content of the test samples is given in table 1. I see that the wikipedia entry for ellagic acid reports ellagic acid has been identified by the u.
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